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#NOTHING ARTIFICIAL NEUROTRACKER MANUAL#
The Multiple Sclerosis Performance Test (MSPT) was used to assess CI via processing speed and PI via manual dexterity or walking speed in 38,041 clinical visits among 13,430 participants in MS PATHS (MS Partners Advancing Technology and Health Solutions). To define patterns of cognitive impairment (CI) and physical impairment (PI) in a large, real-world population of multiple sclerosis patients. Patterns of CI and PI, measured by quantitative performance testing, have not been reported in large, real-world MS populations. The improvement in spasticity with nabiximols was not accompanied by muscle weakness often observed with antispasticity medications, or by a notable change in preferred walking speed.ġ-002 - Patterns of Cognitive and Physical Impairment In A Large, Heterogeneous MS Population: Results From MS PATHS In SAVANT, nabiximols significantly improved spasticity vs placebo (-1.9 p<0.0001), without significantly affecting the T10MW test results (-1.71 p=0.11). In GWSP0604, nabiximols significantly improved mean NRS spasticity score from baseline vs placebo (-0.84 p=0.0002), without significantly affecting the MI for legs (0.97, p=0.439) or the T10MW test results (-3.34 p=0.069). In GWMS0106, nabiximols significantly improved mean NRS spasticity score from baseline vs placebo (-0.52 points p=0.048), without significantly affecting the MI for legs (3.86 p=0.054). The baseline mean (SD) Expanded Disability Status Scale score was 6.0 (1.42) in GWSP0604 and 5.9 (1.1) in SAVANT. This analysis included 184 patients from GWMS0106, 241 from GWSP0604, and 106 from SAVANT. Pearson correlation analysis is being conducted to assess the correlation between spasticity and strength or mobility. Estimated outcome differences between nabiximols and placebo are summarized. Spasticity was evaluated using the Numerical Rating Scale (NRS) in all 3 trials, muscle strength using Motricity Index (MI) in GWMS0106 and GWSP0604, and mobility using timed 10-m walk (T10MW) test in GWSP0604 and SAVANT. Patients who do not respond adequately to conventional antispasticity medications need additional treatment options that improve spasticity without causing weakness.Īssess the relationship between spasticity and muscle strength in lower extremities or mobility, using data from 3 RCTs (GWMS0106, GWSP0604, and SAVANT) of nabiximols vs placebo in patients with spasticity due to MS inadequately controlled by antispasticity medications. Medications that reduce spasticity may also reduce muscle strength, potentially impairing ability to walk. Spasticity is a common feature of MS especially in patients with long-standing illness. We’re experiencing unusually high levels of traffic.
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